Metabolic Deficiencies Underlie Plasmacytoid Dendritic Cell Exhaustion After Viral Infection

bioRxiv[Preprint]. 2024 Mar 3:2024.02.28.582551. doi: 10.1101/2024.02.28.582551. Greene TT, Jo Y, Macal M, Fan […]

Exploratory analysis to predict pneumonitis during durvalumab consolidation therapy for patients with locally advanced non-small cell lung cancer from proteomic profiling of circulating extracellular vesicles

Thorac Cancer. 2023 Aug 24. doi: 10.1111/1759-7714.15077. Torasawa M, Horinouchi H, Yagishita S, Utsumi H, Oku […]

Fibroblast-derived Extracellular Vesicles Induce Lung Cancer Progression in the Idiopathic Pulmonary Fibrosis Microenvironment

Am J Respir Cell Mol Biol. 2023 Jul;69(1):34-44. Fujita Y*, Fujimoto S, Miyamoto A, Kaneko R, Kadota T, Watana […]

Anomalous Epithelial Variations and Ectopic Inflammatory Response in Chronic Obstructive Pulmonary Disease

Am J Respir Cell Mol Biol. 2022 Dec;67(6):708-719. Watanabe N, Fujita Y*, Nakayama J, Mori Y, Kadota T, Hayash […]

Machine Learning-based Exceptional Response Prediction of Nivolumab Monotherapy with Circulating MicroRNAs in Non-Small Cell Lung Cancer.

Lung Cancer. 2022 Nov;173:107-115. Zhang Y, Goto Y, Yagishita S, Shinno Y, Mizuno K, Watanabe N, Yamamoto Y, O […]

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors.

Nat Commun. 2021 Sep 13;12(1):5397. Khateb A, Deshpande A, Feng Y, Finlay D, Lee JS, Lazar I, Fabre B, Li Y, F […]

Human bronchial epithelial cell-derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF-β-WNT crosstalk.

J Extracell Vesicles. 2021 Aug;10(10):e12124. Kadota T, Fujita Y*, Araya J, Watanabe N, Fujimoto S, Kawamoto H […]

Impaired TRIM16-Mediated Lysophagy in Chronic Obstructive Pulmonary Disease Pathogenesis.

J Immunol. 2021 Jul 1;207(1):65-76. Araya J, Saito N, Hosaka Y, Ichikawa A, Kadota T, Fujita Y, Minagawa S, Ha […]

Early prediction of COVID-19 severity using extracellular vesicle COPB2.

J Extracell Vesicles. 2021 Jun;10(8):e12092. Fujita Y*, Hoshina T, Matsuzaki J, Yoshioka Y, Kadota T, Hosaka Y […]

Effectiveness of Switching Biologics for Severe Asthma Patients in Japan: A Single-Center Retrospective Study.

J Asthma Allergy. 2021 Jun 3;14:609-618. Numata T, Araya J, Miyagawa H, Okuda K, Fujita Y, Utsumi H, Takekoshi […]

Single-cell Transcriptome Analysis Reveals an Anomalous Epithelial Variation and Ectopic Inflammatory Response in Chronic Obstructive Pulmonary Disease.

medRxiv. 2020 doi: Watanabe N, Nakayama J, Fujita Y*, Mori Y, Kadot […]

Chaperone-mediated autophagy receptor modulates tumor growth and chemoresistance in non-small cell lung cancer.

Cancer Sci. 2020 Nov;111(11):4154-4165. Ichikawa A, Fujita Y*, Hosaka Y, Kadota T, Ito A, Yagishita S, Watanab […]

Extracellular Vesicles from Fibroblasts Induce Epithelial Cell Senescence in Pulmonary Fibrosis.

Am J Respir Cell Mol Biol. 2020 Nov;63(5):623-636. Kadota T, Yoshioka Y, Fujita Y*, Araya J, Minagawa S, Hara […]

Chaperone-Mediated Autophagy Suppresses Apoptosis via Regulation of the Unfolded Protein Response during Chronic Obstructive Pulmonary Disease Pathogenesis.

J Immunol. 2020 Sep 1;205(5):1256-1267. Hosaka Y, Araya J, Fujita Y, Kadota T, Tsubouchi K, Yoshida M, Minagaw […]

Successful treatment of steroid-refractory immune checkpoint inhibitor-related pneumonitis with triple combination therapy: a case report.

Cancer Immunol Immunother. 2020 Oct;69(10):2033-2039. Utsumi H, Araya J, Okuda K, Watanabe J, Takekoshi D, Fuj […]

Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth.

PrCell Rep. 2020 Feb 11;30(6):1753-1766.e6. Li Y, Elmén L, Segota I, Xian Y, Tinoco R, Feng Y, Fujita Y, Segur […]

Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic Pulmonary Fibrosis Pathogenesis.

J Immunol. 2019 Oct 15;203(8):2076-2087. Tsubouchi K, Araya J, Yoshida M, Sakamoto T, Koumura T, Minagawa S, H […]

Prostaglandin E-Major Urinary Metabolite (PGE-MUM) as a Tumor Marker for Lung Adenocarcinoma.

Cancers (Basel). 2019 Jun 3;11(6):768. Kawamoto H, Hara H, Araya J, Ichikawa A, Fujita Y, Utsumi H, Hashimoto […]

Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5-/- mice.

Nat Commun. 2019 Apr 2;10(1):1492. Li Y, Tinoco R, Elmén L, Segota I, Xian Y, Fujita Y, Sahu A, Zarecki R, Mar […]

Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis.

J Immunol. 2019 Mar 1;202(5):1428-1440. Saito N, Araya J, Ito S, Tsubouchi K, Minagawa S, Hara H, Ito A, Nakan […]

PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.

Autophagy. 2019 Mar;15(3):510-526. Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, Hosaka Y, Ichikawa […]

Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis.

Cell Rep. 2018 Sep 18;24(12):3296-3311.e6. Fujita Y, Khateb A, Li Y, Tinoco R, Zhang T, Bar-Yoseph H, Tam MA, […]

Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival.

EMBO J. 2018 Oct 15;37(20):e99735. Pathria G, Scott DA, Feng Y, Sang Lee J, Fujita Y, Zhang G, Sahu AD, Ruppin […]

Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4+ T Cells

J Immunol. 2018 Apr 15;200(8):2690-2702. Tinoco R, Carrette F, Henriquez ML, Fujita Y, Bradley LM.

Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4.

Autophagy. 2017 Aug 3;13(8):1420-1434. Tsubouchi K, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, Kadota T […]

Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy.

Respir Res. 2017 Jun 2;18(1):114. Kurita Y, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, Kadota T, Tsubou […]

The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity

Cell. 2016 Dec 1;167(6):1525-1539.e17. Moroishi T, Hayashi T, Pan WW, Fujita Y, Holt MV, Qin J, Carson DA, Gua […]

Metformin attenuates lung fibrosis development via NOX4 suppression.

Respir Res. 2016 Aug 30;17(1):107. Sato N, Takasaka N, Yoshida M, Tsubouchi K, Minagawa S, Araya J, Saito N, F […]

Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis.

J Immunol. 2016 Jul 15;197(2):504-16. Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, Sato N, Yos […]

Chemotherapy-Regulated microRNA-125-HER2 Pathway as a Novel Therapeutic Target for Trastuzumab-Mediated Cellular Cytotoxicity in Small Cell Lung Cancer.

Mol Cancer Ther. 2015 Jun;14(6):1414-23. Yagishita S, Fujita Y, Kitazono S, Ko R, Nakadate Y, Sawada T, Kitamu […]

Immunohistochemical status of PD-L1 in thymoma and thymic carcinoma.

Lung Cancer. 2015 May;88(2):154-9. Katsuya Y, Fujita Y, Horinouchi H, Ohe Y, Watanabe S, Tsuta K.

The Clinical Relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 Network in Chemoresistant Non-small-cell Lung Cancer

Mol Ther. 2015 Apr;23(4):717-27. Fujita Y, Yagishita S, Hagiwara K, Yoshioka Y, Kosaka N, Takeshita F, Fujiwar […]

Development of small RNA delivery systems for lung cancer therapy.

Int J Mol Sci. 2015 Mar 6;16(3):5254-70. Fujita Y, Kuwano K, Ochiya T.

Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer.

Oncotarget. 2015 Feb 20;6(5):3335-45. Fujita Y, Yagishita S, Takeshita F, Yamamoto Y, Kuwano K, Ochiya T.

Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis.

J Extracell Vesicles. 2015 Nov 11;4:28388. Fujita Y, Araya J, Ito S, Kobayashi K, Kosaka N, Yoshioka Y, Kadota […]

A novel platform to enable inhaled naked RNAi medicine for lung cancer.

Sci Rep. 2013 Nov 25;3:3325. Fujita Y, Takeshita F, Mizutani T, Ohgi T, Kuwano K, Ochiya T.